Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review
Background and Aims: Diabetes mellitus type 2 (DM-2) is one of the most recurrent chronic diseases worldwide, it is usually treated with synthetic medications, many of which have important repercussions on the patient's body. For this reason, ethnopharmacology has become more important in recen...
| Auteurs principaux: | , , , |
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| Format: | Online |
| Langue: | eng spa |
| Publié: |
Instituto de Ecología, A.C.
2018
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| Accès en ligne: | https://abm.ojs.inecol.mx/index.php/abm/article/view/1361 |
| _version_ | 1799771339379179520 |
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| author | Cadena-Zamudio, Jorge David Nicasio-Torres, María del Pilar Guerrero-Analco, José Antonio Ibarra-Laclette, Enrique |
| author_facet | Cadena-Zamudio, Jorge David Nicasio-Torres, María del Pilar Guerrero-Analco, José Antonio Ibarra-Laclette, Enrique |
| author_sort | Cadena-Zamudio, Jorge David |
| collection | ABM |
| description | Background and Aims: Diabetes mellitus type 2 (DM-2) is one of the most recurrent chronic diseases worldwide, it is usually treated with synthetic medications, many of which have important repercussions on the patient's body. For this reason, ethnopharmacology has become more important in recent years, because a large number of plant resources origin are used in medicine and are shown as positive effect in the treatment of different diseases, including DM-2. Therefore, the aim of this review is to highlight how previous studies are adding to the understanding and knowledge of the biological effects reported in Cecropia obtusifolia, a tropical plant included in the Herbal Pharmacopoeia of the United Mexican States (FHEUM), which is commonly used to treat DM-2.Methods: A profound literature review was carried out on C. obtusifolia, focusing on diverse phytochemical, pharmacological, clinical and toxicological studies, as well as on some other relevant research findings.Key results: It is recognized that this species is able to decrease serum glucose, cholesterol and triglyceride levels due to its hypoglycemic and hypolipidemic properties, which has been demonstrated both in animal and human experimental models, attributing these effects to chlorogenic acid and isoorientin. These previous reports suggest that C. obtusifolia is a promising candidate for the development of a phytopharmaceutical which could be used in the treatment of DM-2.Conclusions: We provide an updated and complete overview of the phytochemistry, traditional uses, and pharmacological activities of C. obtusifolia. Regarding its pharmacological activities, we focus mainly on the hypoglycemic effect of this plant which supports its traditional use in DM-2 control. Moreover, the present knowledge was critically assessed to provide some evidence and justifications and propose future research prospects. |
| format | Online |
| id | oai:oai.abm.ojs.inecol.mx:article-1361 |
| institution | Acta Botanica Mexicana |
| language | eng spa |
| publishDate | 2018 |
| publisher | Instituto de Ecología, A.C. |
| record_format | ojs |
| spelling | oai:oai.abm.ojs.inecol.mx:article-13612022-11-17T21:55:09Z Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review Estudios etnofarmacológicos de Cecropia obtusifolia (Urticaceae) y su importancia en el tratamiento de la diabetes mellitus tipo 2 (DM-2): una mini-revisión Cadena-Zamudio, Jorge David Nicasio-Torres, María del Pilar Guerrero-Analco, José Antonio Ibarra-Laclette, Enrique chlorogenic acid hypoglycemic effect ethnopharmacology medicinal plants ácido clorogénico efecto hipoglucémiante etnofarmacología plantas medicinales Background and Aims: Diabetes mellitus type 2 (DM-2) is one of the most recurrent chronic diseases worldwide, it is usually treated with synthetic medications, many of which have important repercussions on the patient's body. For this reason, ethnopharmacology has become more important in recent years, because a large number of plant resources origin are used in medicine and are shown as positive effect in the treatment of different diseases, including DM-2. Therefore, the aim of this review is to highlight how previous studies are adding to the understanding and knowledge of the biological effects reported in Cecropia obtusifolia, a tropical plant included in the Herbal Pharmacopoeia of the United Mexican States (FHEUM), which is commonly used to treat DM-2.Methods: A profound literature review was carried out on C. obtusifolia, focusing on diverse phytochemical, pharmacological, clinical and toxicological studies, as well as on some other relevant research findings.Key results: It is recognized that this species is able to decrease serum glucose, cholesterol and triglyceride levels due to its hypoglycemic and hypolipidemic properties, which has been demonstrated both in animal and human experimental models, attributing these effects to chlorogenic acid and isoorientin. These previous reports suggest that C. obtusifolia is a promising candidate for the development of a phytopharmaceutical which could be used in the treatment of DM-2.Conclusions: We provide an updated and complete overview of the phytochemistry, traditional uses, and pharmacological activities of C. obtusifolia. Regarding its pharmacological activities, we focus mainly on the hypoglycemic effect of this plant which supports its traditional use in DM-2 control. Moreover, the present knowledge was critically assessed to provide some evidence and justifications and propose future research prospects. Antecedentes y Objetivos: La diabetes mellitus tipo 2 (DM-2) es una de las enfermedades crónicas recurrentes más comunes, generalmente se trata con medicamentos sintéticos, muchos de los cuales tienen importantes repercusiones en el cuerpo del paciente. Por esta razón, la etnofarmacología se ha vuelto más importante en los últimos años, porque una gran cantidad de recursos de origen vegetal son utilizados en medicina y muestran un efecto positivo en el tratamiento de diferentes enfermedades, incluyendo DM-2. Por lo tanto, el objetivo de esta revisión es destacar cómo los estudios previos se suman a la comprensión y el conocimiento de los efectos biológicos informados en Cecropia obtusifolia, una planta tropical incluida en la Farmacopea Herbolaria de los Estados Unidos Mexicanos (FHEUM), comúnmente usada para tratar DM-2.Métodos: Se realizó una revisión profunda de la literatura sobre C. obtusifolia, centrándose en diversos estudios fitoquímicos, farmacológicos, clínicos y toxicológicos, así como en otros hallazgos relevantes de investigación.Resultados clave: Se reconoce que esta especie es capaz de disminuir los niveles séricos de glucosa, colesterol y triglicéridos, debido a sus propiedades hipoglucémicas e hipolipidémicas reductoras de lípidos, que se han demostrado tanto en modelos experimentales animales como en humanos, atribuyendo estos efectos al ácido clorogénico y la isoorienina. Estos informes previos sugieren que C. obtusifolia es un candidato prometedor para el desarrollo de un fitofarmacéutico que podría usarse en el tratamiento de DM-2.Conclusiones: Brindamos una visión general actualizada y completa de la fitoquímica, los usos tradicionales y las actividades farmacológicas de C. obtusifolia. En cuanto a sus actividades farmacológicas, nos centramos principalmente en el efecto hipoglucémico de esta planta que apoya su uso tradicional en el control de DM-2. Además, el conocimiento actual se evaluó críticamente para proporcionar algunas pruebas y justificaciones y proponer futuras perspectivas de investigación. Instituto de Ecología, A.C. 2018-10-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/epub+zip application/xml https://abm.ojs.inecol.mx/index.php/abm/article/view/1361 10.21829/abm126.2019.1361 Acta Botanica Mexicana; No. 126 (2019) Acta Botanica Mexicana; Núm. 126 (2019) 2448-7589 0187-7151 eng spa https://abm.ojs.inecol.mx/index.php/abm/article/view/1361/3970 https://abm.ojs.inecol.mx/index.php/abm/article/view/1361/3971 https://abm.ojs.inecol.mx/index.php/abm/article/view/1361/1752 Derechos de autor 2018 Acta Botanica Mexicana https://creativecommons.org/licenses/by-nc/4.0 |
| spellingShingle | Cadena-Zamudio, Jorge David Nicasio-Torres, María del Pilar Guerrero-Analco, José Antonio Ibarra-Laclette, Enrique Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review |
| title | Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review |
| title_full | Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review |
| title_fullStr | Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review |
| title_full_unstemmed | Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review |
| title_short | Ethnopharmacological studies of Cecropia obtusifolia (Urticaceae) and its importance in the treatment of type 2 diabetes mellitus: A mini-review |
| title_sort | ethnopharmacological studies of cecropia obtusifolia (urticaceae) and its importance in the treatment of type 2 diabetes mellitus: a mini-review |
| url | https://abm.ojs.inecol.mx/index.php/abm/article/view/1361 |
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